The XDRO registry is a product of collaboration between IDPH, Medical Research Analytics and Informatics Alliance (MRAIA), and the Chicago CDC Prevention Epicenter.

Reporting Rule

Starting November 1, 2013, the first CRE-positive culture per patient stay must be reported to the XDRO registry.


CRE definition

Enterobacterales (e.g., E. coli, Klebsiella species, Enterobacter species, Proteus species, Citrobacter species, Serratia species, Morganella species, or Providentia species) with one of the following laboratory test results:

  1. Molecular test (e.g., polymerase chain reaction [PCR]) specific for carbapenemase;
  2. Phenotypic test (e.g., Modified Hodge) specific for carbapenemase production;
  3. For E. coli and Klebsiella species only (excluding K. aerogenes): non-susceptible (intermediate or resistant) to ONE of the following carbapenems (doripenem, meropenem, or imipenem) AND resistant to ALL of the following third generation cephalosporins tested (ceftriaxone, cefotaxime, and ceftazidime). Note: ignore ertapenem for this definition.

Consult with your microbiology laboratory regarding which CRE tests are available. For some laboratories, only #3 will be available.


Carbapenem-Resistant Acinetobacter baumannii (CRAB) definition

Acinetobacter baumannii with one of the following laboratory test results:

  1. Molecular test (e.g., polymerase chain reaction [PCR]) specific for carbapenemase, or
  2. Resistant to at least one of the following carbapenems (doripenem, meropenem, or imipenem). Note: ignore ertapenem for this definition.

Candida auris (C. auris) definition

Confirmatory laboratory evidence of Candida auris using either culture or a validated culture-independent test (e.eg., NAAT [Nucleic Acid Amiplification Test]).


Carbapenemase Producing – Carbapenem Resistant Pseudomonas aeruginosa (CP-CRPA) definition

Pseudomonas aeruginosa with one of the following laboratory test results:

  1. Molecular test (e.g. polymerase chain reaction [PCR]) specific for carbapenemase, or
  2. Phenotypic test specific for carbapenemase production.

From the Joint Committee on Administrative Rules – Administrative Code

TITLE 77: PUBLIC HEALTH
CHAPTER I: DEPARTMENT OF PUBLIC HEALTH
SUBCHAPTER k: COMMUNICABLE DISEASE CONTROL AND IMMUNIZATIONS
PART 690 CONTROL OF NOTIFIABLE DISEASES AND CONDITIONS CODE

SUBPART D: DETAILED PROCEDURES FOR THE CONTROL OF NOTIFIABLE DISEASES AND CONDITIONS

  • SECTION 690.540 MULTI-DRUG RESISTANT ORGANISMS CONSIDERED TO BE OF EPIDEMIOLOGIC IMPORTANCE DUE TO EITHER SEVERITY OF CLINICAL DISEASE, POTENTIAL FOR TRANSMISSION OF GENETIC ELEMENTS, OR OPPORTUNITIES FOR EFFECTIVE CONTROL EFFORTS (REPORTABLE BY TELEPHONE, FACSIMILE, OR ELECTRONICALLY AS SOON AS POSSIBLE, WITHIN THREE DAYS)

SUBPART J: REGISTRIES

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